The founding fathers of the quantum revolution were deeply invested in questions of meaning. Distanced from theology but also from the deterministic objective Materialism of the classical model of physics, several of them, including Bohr, Heisenberg, Pauli, Schrödinger and Bohm looked to Eastern philosophies for explanations. This search for meaning beyond church and clockwork seems to have stagnated in our times. Yet, recent advances in physics and the reinterpretation of historic experiments have given us new ways to understand and ask fundamental philosophical questions. These approaches include further considerations of the Copenhagen Interpretation of Bohr, Heisenberg and others, the Transactional Interpretation of John G. Cramer and Ruth Krastner, Quantum Bayesianism (QBism) of Fuchs, Schack and David Mermin; questions related to the meaning of observation and measurement; the Orthodox view of quantum mechanics; collapse of the wave function and time and quantum field theory. The present volume brings together a number of these approaches discussed by leading contemporary physicists. It also expands the consideration of the quantum revolution to include its larger implications for philosophy, mathematics, biology and global understanding, reopening the questions of consciousness and meaning which occupied the minds of the early thinkers of Quantum Mechanics.